Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice
نویسندگان
چکیده
منابع مشابه
Novel insight into a platelet-derived growth factor-C/Smad3 axis in liver fibrosis. Focus on "Role of Smad3 in platelet-derived growth factor-C-induced liver fibrosis".
LIVER FIBROSIS IS THE COMMON RESPONSE to chronic liver injury and is due to the abnormal accumulation of extracellular matrix (ECM). In response to injury, activated hepatic stellate cells (HSCs) proliferate and produce excess amounts of ECM in response to inflammatory cytokines and growth factors (1, 2, 7). Among these mediators, transforming growth factor(TGF) is the major profibrogenic cytok...
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Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFR...
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Chronic liver injury leads to fibrosis, cirrhosis, and loss of liver function. Liver cirrhosis is the 12th leading cause of death in the United States, and it is the primary risk factor for developing liver cancer. Fibrosis and cirrhosis result from activation of hepatic stellate cells (HSCs), which are the primary collagen producing cell type in the liver. Here, we show that platelet-derived g...
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BACKGROUND Platelet-derived growth factor receptor alpha (PDGFRα) is a cell-surface receptor tyrosine kinase for platelet-derived growth factors. Correct timing and level of Pdgfra expression is crucial for embryo development, and deletion of Pdgfra caused developmental defects of multiple endoderm and mesoderm derived structures, resulting in a complex phenotypes including orofacial cleft, spi...
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Here we present the cloning of a full-length zebrafish pdgfr-a cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-a mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted expression of the gene started after the onset of segmentation and is mainly localized i...
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ژورنال
عنوان ژورنال: Cell Communication and Signaling
سال: 2018
ISSN: 1478-811X
DOI: 10.1186/s12964-018-0306-2